Table 1 Telomere and telomerase in human stem cells

From: Telomere and telomerase in stem cells

Cell type

Lineage

Growth

Telomerase

Telomere

Reference

Embryonic

All tissue

Unlimited

High

Maintained

 

Hematopoietic

Multipotent

Limited

Absent/low

Shortened

Brummendorf and Balabanov (2006)

Mesenchymal

Multipotent/skeletal tissue

Limited/unlimited

Absent/low upregulated by stimuli

Shortened/maintained

(Izadpanah et al, 2006; Yanada et al, 2006; Zimmermann et al, 2003)

Skin

Epidermis

Limited

Low

Shortened

(Sarin et al, 2005; Sugihara et al, 1999)

Hair follicle

Hair

Limited

Low

Shortened

 

Intestinal crypt

Intestinal mucosa

Limited

Low

Shortened

(Hiyama et al, 1996)

Neuronala

Several neurons

Limited

Low/absent

Shortened

(Wright et al, 2006)

Pancreatica

Ductal epithelial

Limited

Absent

Shortened

(Moriscot et al, 2005)

Liver epithelial

Bi-potential

Limited (durable)

Low

Maintained/shortened

(Dan et al, 2006)

Cancer stem cell

Multipotent

Unlimited

High

Maintained

(Hertzog, 2006)

  1. aThese stem cells may be derived from hMSCs.