Figure 1

Results obtained from luciferase assays where pGL3 or pGL/WTH3P was cotransfected with pcDNA3.1, pcDNA/P53 or pcDNA/P53R249S into (A) MCF7/WT and (B) HEK293 cells. Relative luciferase activities driven by the WTH3 promoter under the influence of the empty vector, wild-type and mutated p53 were compared.