Table 1a Clinicopathological parameters in relation to p53, BAX and Bcl-2 protein expression (n=188)
BSI (no. (%)) | Bcl-2 (no. (%)) | p53 (no. (%)) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
n | High | Low | P | High | Low | P | Positive | Negative | P | |
Sex | ||||||||||
Male | 79 | 44 (55.7) | 35 (44.3) | 0.43 | 52 (65.8) | 27 (44.2) | 0.33 | 42 (53.2) | 37 (46.8) | 0.46 |
Female | 109 | 67 (61.5) | 42 (38.5) | 79 (72.5) | 30 (27.5) | 52 (47.7) | 57 (52.3) | |||
Age, years | ||||||||||
⩽62 | 98 | 63 (64.3) | 35 (35.7) | 0.13 | 68 (69.4) | 30 (30.6) | 0.93 | 52 (53.1) | 46 (46.9) | 0.38 |
>62 | 90 | 48 (53.3) | 42 (46.7) | 63 (70.0) | 27 (30.0) | 42 (46.7) | 48 (53.3) | |||
T category, pathologic | ||||||||||
T2 | 19 | 11 (57.9) | 8 (42.1) | 0.92 | 15 (78.9) | 4 (21.1) | 0.35 | 10 (52.6) | 9 (47.4) | 0.81 |
T3–4 | 169 | 100 (59.2) | 69 (40.8) | 116 (68.6) | 53 (31.4) | 84 (49.7) | 85 (50.3) | |||
N category, pathologic | ||||||||||
N1 | 107 | 67 (62.6) | 40 (37.4) | 0.25 | 75 (70.1) | 32 (29.9) | 0.89 | 49 (45.8) | 58 (54.2) | 0.19 |
N2–3 | 81 | 44 (54.3) | 37 (45.7) | 56 (69.1) | 25 (30.9) | 45 (55.6) | 36 (44.4) | |||
Differentiation | ||||||||||
G1–2 | 138 | 89 (64.5) | 49 (35.5) | 0.01 | 97 (70.3) | 41 (29.7) | 0.76 | 69 (50.0) | 69 (50.0) | 1 |
G3–4 | 50 | 22 (44.0) | 28 (56.0) | 34 (68.0) | 16 (32.0) | 25 (50.0) | 25 (50.0) | |||
Location | ||||||||||
Right | 93 | 51 (54.8) | 42 (45.2) | 0.25 | 58 (62.4) | 35 (37.6) | 0.03 | 43 (46.2) | 50 (53.8) | 0.31 |
Left | 95 | 60 (63.2) | 35 (36.8) | 73 (76.8) | 22 (23.2) | 51 (53.7) | 44 (46.3) | |||
Treatment arm | ||||||||||
Arm A (5-FU/LV) | 95 | 56 (58.9) | 39 (41.1) | 0.98 | 69 (72.6) | 26 (27.4) | 0.37 | 44 (46.3) | 51 (53.7) | 0.31 |
Arm B (5-FU/LEV) | 93 | 55 (59.1) | 38 (40.9) | 62 (66.7) | 31 (33.3) | 50 (53.8) | 43 (46.2) | |||
