Table 5 Multivariate analysis of clinicopathological and genetic parameters for OS (Cox regression hazard analysis)

From: Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX

 

OS

Prognostic factor

P -values

Hazard ratio

95% CI

Step 1

pT category

 T3/4

0.27

2

0.6–6.3

pN category

 N2/3

0.001

2.3

1.4–3.8

Differentiation

 G3/4

0.18

1.4

0.9–2.4

Treatment arm

 Arm B (5-FU/LEV)

0.02

1.8

1.1–3.8

BSI

 Low

0.004

2.1

1.3–3.4

Step 3

pN category

 N2/3

<0.0001

2.5

1.5–4.2

BSI

 Low

0.003

2.1

1.3–3.5

Treatment arm

 Arm B (5-FU/LEV)

0.01

1.9

1.1–3.1

  1. CI=confidence interval; 5-FU=5-fluorouracil; LEV=levamisole; OS=overall survival. Bold values signify P<0.05.
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