Figure 4 | British Journal of Cancer

Figure 4

From: Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer

Figure 4

(A) Histological appearance of the left femur of a control mouse (untreated, no cell injections) stained for TRAP. No osteoclasts were observed. (B–E) Histological appearance of skeletal tumours in the left femora of mice injected with MDA-MB-231 cells showing TRAP-positive osteoclasts (arrowheads). Mice were treated with (B) placebo, (C) doxycycline, (D) zoledronic acid or (E) with both doxycycline and zoledronic acid. (Original magnification × 400, Bar=20 μm). Bo, bone; Tu, tumour; arrowheads, osteoclasts.

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