Table 2 CD20, RKIP and bcl-2 expression levels in specimen of cutaneous lymphoma relapse obtained at different time points since treatment start

From: Bcl-2 expression in rituximab refractory cutaneous B-cell lymphoma

  

CD20-positive cells (%)

RKIP-positive cells (%)

Bcl-2-positive cells (%)

Patients

Timepoint of biopsy

<10

10–30

30–60

60–90

>90

<10

10–30

30–60

60–90

>90

<10

10–30

30–60

60–90

>90

Patient 1

At diagnosis

    

x

x

     

x

   
 

At relapse after 4 months (during therapy)

 

x

      

x

     

x

 

At relapse after 6 months (during therapy)

   

x

    

x

     

x

 

At relapse after 12 months (during therapy)

   

x

    

x

     

x

Patient 2

At diagnosis

 

x

   

x

      

x

  
 

At relapse after 6 months (5 months since therapy cessation)

 

x

      

x

   

x

  
 

At relapse after 9 months (8 months since therapy cessation)

 

x

      

x

    

x

 

Patient 3

At diagnosis

   

x

   

x

      

x

 

At relapse after 13 months (6 months since therapy cessation)

   

x

    

x

     

x

Patient 4

At relapse after 4 months (2 months since therapy cessation)

 

x

     

x

    

x

  
 

At relapse after 30 months (28 months since therapy cessation)

 

x

      

x

    

x

 
  1. RKIP=Raf-kinase inhibitory protein.
  2. Repetitive biopsies were obtained either during (patient 1) or after (patients 2–4) rituximab therapy.