Table 1 Outcome probabilities used in the model

From: Cost-effectiveness analysis of anastrozole vs tamoxifen in adjuvant therapy for early stage breast cancer in the United Kingdom: the 5-year completed treatment analysis of the ATAC (‘Arimidex’, Tamoxifen alone or in combination) trial

 

Anastrozole

Tamoxifen

Distribution

Probabilistic parameters

Distant recurrences as a proportion of all recurrences during recurrence benefita

0.66

0.60

β

Anastrozole: α, 186; β, 96

Tamoxifen: α, 222, β, 148

    

Adverse events b

 Life-threatening

0.047

0.066

β

Anastrozole: α, 142; β, 2950

Tamoxifen: α, 201, β, 2893

 Non life-threatening

0.698

0.657

β

Anastrozole: α, 2163; β, 929

Tamoxifen: α, 2037, β, 1057

 None

0.255

0.277

Remainder

 

Following local/regional recurrence

 Distant metastases-free at 5 yearsc

 

0.52

β

α, 73; β, 67

 Distant metastases-free after 5 yearsd

 

0.77

β

α, 91; β, 27

 Death due to breast cancere

 

0.222

β

α, 26; β, 140

Following distant recurrence

 Overall survival at 2 yearsf

 

0.50

β

α, 155; β, 155

  1. aNote that the overall number of recurrences was lower in the anastrozole arm (282) than in the tamoxifen arm (370); percentages are calculated based on recurrences occurring as a first event, estimated from ATAC data (anastrozole 186, tamoxifen 222), and the uncertainty in these estimates was compensated for by assigning a distribution to these estimates in the probabilistic sensitivity analysis; the estimates assume the benefits of anastrozole continued out to 10 years from initiation of treatment.
  2. bFrom the 68-month median follow-up of ATAC trial patients (ATAC Trialists' Group, 2005).
  3. cFrom Kamby and Sengeløv (1997).
  4. dFrom Moran and Haffty (2002).
  5. eEstimated from the median 68-month follow-up data of ATAC trial patients (ATAC Trialists' Group, 2005).
  6. fFrom Stockler et al (2000).