Table 1 Outcome probabilities used in the model
Anastrozole | Tamoxifen | Distribution | Probabilistic parameters | |
---|---|---|---|---|
Distant recurrences as a proportion of all recurrences during recurrence benefita | 0.66 | 0.60 | β | Anastrozole: α, 186; β, 96 |
Tamoxifen: α, 222, β, 148 | ||||
Adverse events b | ||||
Life-threatening | 0.047 | 0.066 | β | Anastrozole: α, 142; β, 2950 |
Tamoxifen: α, 201, β, 2893 | ||||
Non life-threatening | 0.698 | 0.657 | β | Anastrozole: α, 2163; β, 929 |
Tamoxifen: α, 2037, β, 1057 | ||||
None | 0.255 | 0.277 | Remainder | |
Following local/regional recurrence | ||||
Distant metastases-free at 5 yearsc | 0.52 | β | α, 73; β, 67 | |
Distant metastases-free after 5 yearsd | 0.77 | β | α, 91; β, 27 | |
Death due to breast cancere | 0.222 | β | α, 26; β, 140 | |
Following distant recurrence | ||||
Overall survival at 2 yearsf | 0.50 | β | α, 155; β, 155 |