Table 2 Estimated costs of medical management, death and adverse events used in the model^a

	Cost (£)	s.d. ^b
Treatment/diagnosis (cost/event)
At treatment initiation	90	38
Diagnosis of recurrence	808	92
Treatment for local/regional recurrence	2606	2085^a
Treatment for distant recurrence	3563	2850^a
Follow-up and monitoring (cost/cycle)
Follow-up for local/regional recurrence	143	66
Follow-up for distant recurrence	199	95
Routine follow-up
Years 1	70	20
Years 2+	43	17
Follow-up off treatment due to remission	24	18
Follow-up off treatment due to adverse events	51	43
Death (cost/year)
Death from breast cancer^c	3783	3404
Death from other causes	500	450
Adverse event
Fractures^d		NA
Wrist	1463	NA
Spine	2915	NA
Hip	10 682	NA
Ischaemic cerebrovascular event	6299	NA
Deep venous thromboembolism^e	2110	NA
Endometrial cancer	2245	NA
Hysterectomy	1873	NA
Ischaemic cardiovascular disease	3251	NA
Vaginal bleeding	1407	NA
Hot flushes	239	NA
Musculoskeletal disorders	533	NA
Mood disturbances	109	NA
Fatigue	20	NA
Nausea and vomiting	20	NA
Vaginal discharge	240	NA
Bisphosphonate treatment	1432	NA

Abbreviation: NA=not applicable.
^aOn the basis of physician survey, MEDTAP unit cost database and NHS reference costs (Department of Health, 2003), except where stated.
^bCosts were assumed to follow a γ-distribution.
^cFrom Coyle et al (1999).
^dFrom Iglesias et al (2002).
^eFrom Gordois et al (2003).

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