Figure 2
Graphical representation of array-CGH analysis of tumours from Patients 2 and 16 (whole genome). Vertical lines indicate the boundaries of the chromosomes. (A) In Patient 2, a concordant pattern was found in 4q32-35, 6q15-22, 9p21-24, 9q, 11p, 17p (loss) and 20q (gain). A later tumour (T3) had additional genetic alterations (2p, 2q (gain)). (B) In Patient 16, several discordant patterns were found in 11p, 13q22-tel, 17p, 18q, and 20p. Average log 2 ratios were plotted for all clones at the chromosome positions. Thresholds for gain or loss are shown within log 2 ratios of 0.3 and −0.3, respectively. Arrows indicate the differences of the pattern of chromosomal aberrations between tumour pairs. T=tumour; Chr=chromosome.
