Table 1 Associations between COX2 variants and prostate cancer risk
From: COX2 genetic variation, NSAIDs, and advanced prostate cancer risk
All groups a | African Americans b | Caucasians b | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
SNP | Cases, n (%) | Controls, n (%) | OR (95% CI) | Cases, n (%) | Controls, n (%) | OR (95% CI) | Cases, n (%) | Controls, n (%) | OR (95% CI) | |
rs689466 | AA | 337 (66.6) | 357 (70.6) | 1.00 | 67 (75.3) | 77 (86.5) | 1.00 | 270 (49.1) | 280 (67.2) | 1.00 |
AG | 154 (30.4) | 134 (26.5) | 1.22 (0.93–1.61) | 20 (22.5) | 12 (13.5) | 1.94 (0.88–4.28) | 134 (32.1) | 122 (29.3) | 1.14 (0.85–1.53) | |
GG | 15 (3.0) | 15 (3.0) | 1.06 (0.51–2.21) | 2 (2.3) | 0 (0) | — | 13 (3.1) | 15 (3.6) | 0.90 (0.42–1.92) | |
rs20417c | GG | 332 (65.7) | 331 (65.5) | 1.00 | 38 (42.7) | 38 (43.2) | 1.00 | 294 (70.7) | 293 (70.3) | 1.00 |
GC | 157 (31.1) | 151 (29.9) | 1.03 (0.78–1.36) | 42 (47.2) | 38 (43.2) | 1.10 (0.59–2.07) | 115 (27.6) | 113 (27.1) | 1.01 (0.75–1.38) | |
CC | 16 (3.2) | 23 (4.6) | 0.68 (0.35–1.33) | 9 (10.1) | 12 (13.6) | 0.75 (0.28–1.99) | 7 (1.7) | 11 (2.6) | 0.63 (0.24–1.66) | |
rs2745557 | GG | 364 (71.9) | 318 (62.9) | 1.00 | 69 (77.5) | 56 (62.9) | 1.00 | 295 (70.7) | 262 (62.8) | 1.00 |
GA | 126 (24.9) | 172 (34.0) | 0.64 (0.49–0.84)e | 19 (21.4) | 30 (33.7) | 0.51 (0.26–1.01) | 107 (25.7) | 142 (34.1) | 0.67 (0.50–0.90)f | |
AA | 16 (3.2) | 16 (3.2) | 0.87 (0.43–1.78) | 1 (1.1) | 3 (3.4) | 0.27 (0.03–2.68) | 15 (3.6) | 13 (3.1) | 1.02 (0.48–2.20) | |
rs5277 | CC | 359 (71.1) | 384 (75.9) | 1.00 | 86 (96.6) | 83 (93.3) | 1.00 | 273 (65.6) | 301 (72.2) | 1.00 |
CG | 134 (26.5) | 116 (22.9) | 1.25 (0.93–1.68) | 3 (3.4) | 6 (6.7) | 0.48 (0.12–1.99) | 131 (31.5) | 110 (26.4) | 1.32 (0.97–1.78) | |
GG | 12 (2.4) | 6 (1.2) | 2.18 (0.81–5.90) | 0 (0) | 0 (0) | — | 12 (2.9) | 6 (1.4) | 2.21 (0.82–5.99) | |
rs2066826 | AA | 353 (69.8) | 341 (67.5) | 1.00 | 39 (43.8) | 32 (36.4) | 1.00 | 314 (75.3) | 309 (74.1) | 1.00 |
AG | 140 (27.7) | 142 (28.1) | 0.94 (0.70–1.25) | 42 (47.2) | 44 (50.0) | 0.78 (0.42–1.47) | 98 (23.5) | 98 (23.5) | 0.98 (0.71–1.36) | |
GG | 13 (2.6) | 22 (4.4) | 0.55 (0.27–1.13) | 8 (9.0) | 12 (13.6) | 0.55 (0.20–1.50) | 5 (1.2) | 10 (2.4) | 0.49 (0.17–1.46) | |
rs5275 | AA | 195 (38.6) | 207 (40.9) | 1.00 | 12 (13.5) | 11 (12.4) | 1.00 | 183 (44.0) | 196 (47.0) | 1.00 |
AG | 238 (47.1) | 226 (44.7) | 1.06 (0.70–1.58) | 39 (43.8) | 49 (55.1) | 0.73 (0.29–1.85) | 199 (47.8) | 177 (42.5) | 1.21 (0.91–1.60) | |
GG | 72 (14.3) | 73 (14.4) | 1.12 (0.86–1.47) | 38 (42.7) | 29 (32.6) | 1.20 (0.46–3.14) | 34 (8.2) | 44 (10.6) | 0.83 (0.51–1.35) | |
rs2206593d | CC | 466 (92.1) | 438 (86.7) | 1.00 | 87 (97.8) | 85 (96.6) | 1.00 | 379 (90.9) | 353 (84.7) | 1.00 |
CT | 40 (7.9) | 64 (12.7) | 0.58 (0.38–0.89)g | 2 (2.3) | 3 (3.4) | 0.65 (0.11–4.01) | 38 (9.1) | 61 (14.6) | 0.58 (0.38–0.89)h | |
TT | 0 (0) | 3 (0.6) | — | 0 (0) | 0 (0) | — | 0 (0) | 3 (0.7) | — | |
rs689470 | GG | 422 (83.6) | 434 (85.9) | 1.00 | 25 (28.1) | 33 (37.5) | 1.00 | 397 (95.4) | 401 (96.2) | 1.00 |
GA | 57 (11.3) | 58 (11.5) | 1.19 (0.73–1.93) | 39 (43.8) | 43 (48.9) | 1.20 (0.61–2.37) | 18 (4.3) | 15 (3.6) | 1.21 (0.60–2.43) | |
AA | 26 (5.2) | 13 (2.6) | 2.57 (1.17–5.64)i | 25 (28.0) | 12 (13.6) | 2.79 (1.17–6.64)j | 1 (0.2) | 1 (0.2) | 1.00 (0.06–16.21) | |
rs4648310 | AA | 473 (93.5) | 485 (95.9) | 1.00 | 88 (98.9) | 87 (97.8) | 1.00 | 385 (92.3) | 398 (95.4) | 1.00 |
AG | 30 (5.9) | 20 (4.0) | 1.54 (0.86–2.76) | 1 (1.1) | 2 (2.3) | 0.49 (0.04–5.60) | 29 (7.0) | 18 (4.3) | 1.67 (0.91–3.05) | |
GG | 3 (0.6) | 1 (0.2) | 3.10 (0.32–29.97) | 0 (0) | 0 (0) | — | 3 (0.7) | 1 (0.2) | 3.12 (0.32–30.12) | |
