Figure 8 | British Journal of Cancer

Figure 8

From: The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model

Figure 8

Pathways summary: trichostatin A modulates ABCB1 gene expression in H69 cells (increase in H69WT cells but decrease in H69VP cells). This differential modulation occurs both through a direct action on chromatin and through changes in regulatory factors expression (1). Among these, WTH3 does not play a key role. This modulation occurs through transcriptional mechanisms (2) and is not linked to alterations in RNA stability (3). It is concomitant with differential histone acetylation patterns at the ABCB1 promoter (4), but appears independent of DNA methylation and MBD1 (5) or PCAF recruitment (6) on CCAAT inverted box. Dashed lines represent pathways that cannot explain the differential regulation of ABCB1 expression in H69WT and H69VP cells.

Back to article page