Figure 5 | British Journal of Cancer

Figure 5

From: PLD1 is overexpressed in an ER-negative MCF-7 cell line variant and a subset of phospho-Akt-negative breast carcinomas

Figure 5

Phospholipase D1 (PLD1) and phospho-Akt are inversely expressed in a subset of breast carcinomas. Tissue microarrays (TMAs) were constructed with archived formalin-fixed, paraffin-embedded (FFPE) breast carcinomas, and protein expression was determined by immunohistochemistry (IHC). Representative photographs are shown: row (A), tumour cells show positive staining for PLD1, negative for phospho-Akt, but positive for phospho-mammalian target of rapamycin (mTOR); row (B), PLD1 shows positive expression in stromal cells, but is negative in the tumour cells, whereas phospho-Akt and -mTOR show positive expression in tumour cells; row (C), shows positive expression for PLD1, phospho-Akt, and phospho-mTOR.

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