Table 1 Characteristics of 290 population-based prostate cancer patients aged <55 years at diagnosis screened for BRCA2 mutations
From: Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer
1993–1996 ( n =162) | 2002–2005 ( n =128) | Total case patients ( n =290) | ||||
|---|---|---|---|---|---|---|
Ascertainment period | N | % | N | % | N | % |
Age at diagnosis (years) | ||||||
35–49 | 39 | 24.1 | 58 | 45.3 | 97 | 33.4 |
50–54 | 123 | 75.9 | 70 | 54.7 | 193 | 66.6 |
Race | ||||||
Caucasian | 154 | 95.1 | 103 | 80.5 | 257 | 88.6 |
African-American | 8 | 4.9 | 25 | 19.5 | 33 | 11.4 |
Jewish | ||||||
No | 159 | 98.1 | 126 | 98.4 | 285 | 98.3 |
Yes | 3 | 1.9 | 2 | 1.6 | 5 | 1.7 |
Family history of prostate cancer | ||||||
None | 111 | 68.5 | 71 | 55.5 | 182 | 62.8 |
First-degree | 33 | 20.4 | 40 | 31.3 | 73 | 25.2 |
Second-degree only | 18 | 11.1 | 17 | 13.3 | 35 | 12.1 |
Family history of breast cancer | ||||||
None | 134 | 82.7 | 109 | 85.2 | 243 | 83.8 |
First-degree | 22 | 13.6 | 15 | 11.7 | 37 | 12.8 |
Second-degree only | 6 | 3.7 | 4 | 3.1 | 10 | 3.4 |
Family history of ovarian cancer | ||||||
None | 157 | 96.9 | 123 | 96.1 | 280 | 96.6 |
First-degree | 2 | 1.2 | 3 | 2.3 | 5 | 1.7 |
Second-degree only | 3 | 1.9 | 2 | 1.6 | 5 | 1.7 |
Prostate cancer screeninga | ||||||
None | 32 | 19.8 | 28 | 21.9 | 60 | 20.7 |
DRE only | 46 | 28.4 | 25 | 19.5 | 71 | 24.5 |
PSA and DRE | 84 | 51.9 | 75 | 58.6 | 159 | 54.8 |
Gleason score | ||||||
2–4 | 19 | 11.7 | — | — | 19 | 6.6 |
5–6 | 82 | 50.6 | 69 | 53.9 | 151 | 52.1 |
7 (3+4) | 39 | 24.1 | 40 | 31.3 | 79 | 27.2 |
7 (4+3) | 9 | 5.6 | 11 | 8.6 | 20 | 6.9 |
8–10 | 10 | 6.2 | 6 | 4.7 | 16 | 5.5 |
Missing | 3 | 1.9 | 2 | 1.6 | 5 | 1.7 |
Stage of cancer | ||||||
Localised | 114 | 70.4 | 97 | 75.8 | 211 | 72.8 |
Regional | 40 | 24.7 | 29 | 22.7 | 69 | 23.8 |
Distant | 8 | 4.9 | 2 | 1.6 | 10 | 3.4 |
PSA at diagnosis (ng/ml) b | ||||||
0–3.9 | 26 | 16.1 | 29 | 22.7 | 55 | 19.0 |
4.0–9.9 | 77 | 47.6 | 63 | 49.2 | 140 | 48.3 |
10.0–19.9 | 21 | 12.9 | 15 | 11.7 | 36 | 12.4 |
⩾20 | 19 | 11.7 | 11 | 8.6 | 30 | 10.3 |
Missing | 19 | 11.7 | 10 | 7.8 | 29 | 10.0 |
