Table 2 Characteristics of prostate cancer patients with germline protein-truncating BRCA2 mutations
From: Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer
Case A | Case B | |
|---|---|---|
BRCA2 mutation | ||
Exon location | 11 | 11 |
Nucleotide change | 4625_4629delACATT | 4074_4075delGT |
Protein effect | STOP 1467 | STOP 1284 |
Characteristics | ||
Age at diagnosis (years) | 51 | 47 |
Race | Caucasian | Caucasian |
Family history of | ||
Prostate cancer | Yes (first-degree) | No |
Breast cancer | No | No |
Ovarian cancer | No | No |
Clinical characteristics | ||
Gleason score | 7 (3+4) | 7 (4+3) |
Stage of cancer | Localised | Localised |
PSA at diagnosis (ng/ml) | Missing | 6.3 |
