Table 3 SNPs with a ⩾3% minor allele frequency in the BRCA2 gene among 290 prostate cancer patients, by race

Exon	Nucleotide position	Nucleotide change	Amino-acid change	Genotype	Total N =290	%	Caucasian N =257	%	African American N =33	%	P -value ^a
SNP in the 5′ UTR region
	202	G>A	5′ UTR	GG	160	55.2	139	54.1	21	63.6	0.51
				AG	100	34.5	90	35.0	10	30.3
				AA	30	10.3	28	10.9	2	6.1
Non-synonomous SNPs
10	1092	A>C	N289H	AA	269	92.8	240	93.4	29	87.9	0.25
				AC^b	21	7.2	17	6.6	4	12.1
10	1341	A>C	N372H	AA	170	58.6	142	55.3	28	84.8	0.004
				AC	98	33.8	93	36.2	5	15.2
				CC	22	7.6	22	8.6	—	—
11	3198	A>G	N991D	AA	268	92.4	240	93.4	28	84.8	0.08
				AG^b	22	7.6	17	6.6	5	15.2
11	5971	C>T	T1915M	CC	272	93.8	243	94.6	29	87.9	0.13
				CT^b	18	6.2	14	5.4	4	12.1
Synonomous or intronic SNPs
10	1592	A>G	S455S	AA	269	92.8	240	93.4	29	87.9	0.25
				AG^b	21	7.2	17	6.6	4	12.1
11	2456	T>C	H743H	TT	269	92.8	240	93.4	29	87.9	0.25
				CT^b	21	7.2	17	6.6	4	12.1
11	3623	A>G	K1132K	AA	134	46.2	121	47.1	13	39.4	0.68
				AG	121	41.7	105	40.9	16	48.5
				GG	35	12.1	31	12.1	4	12.1
11	4034	T>C	V1269V^c	TT	195	67.2	171	66.5	24	72.7	0.72
				CT	77	26.6	69	26.8	8	24.2
				CC	16	5.5	15	5.8	1	3.0
14	7469	A>G	S2414S	AA	170	58.6	155	60.3	15	45.5	0.23
				AG	104	35.9	89	34.6	15	45.5
				GG	16	5.5	13	5.1	3	9.1
17	IVS17-14	T>C	intronic	CC	86	29.7	70	27.2	16	48.5	0.04
				CT	134	46.2	123	47.9	11	33.3
				TT	70	24.1	64	24.9	6	18.2

^aχ² P-value comparing the distribution of genotypes between Caucasian and African-American prostate cancer cases.
^bNo homozygous variants were detected.
^cTwo Caucasian men had missing data for this SNP and thus percentages do not add up to 100%.

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