Table 1 Micronucleation, apoptosis and spindle pole status in CC and PSP sublines after paclitaxel treatment

From: Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype

 

MN-BN a

Apoptosis b

Spindle pole status c

       

Control

Paclitaxel 1 n M

Paclitaxel 20 n M

 

Control

Paclitaxel 1 n M

Paclitaxel 20 n M

Control

Paclitaxel 1 n M

Paclitaxel 20 n M

SP=2

SP>2

SP=2

SP>2

SP=2

SP>2

CC

0.0

1.1

ND

0.2

3.5

62.6

95.5

4.5

86.0

13.9

26.8

73.2

PSP

4.9

4.9*

42.5

0.5

1.2*

34.5***

95.1

4.9

92.7

7.3

14.8

85.2

  1. PSP, paclitaxel-surviving population.
  2. aPercentage of binucleated cells showing micronucleation; values represent mean percentage of micronucleated cells in CC (n=10) and PSP subline (n=20) groups.
  3. bPercentage of cells showing apoptotic morphology; values represent mean percentage of apoptotic cells in CC (n=10) and PSP subline (n=20) groups.
  4. cPercentage of mitotic cells with 2 (SP=2) or more spindle poles (SP>2); values represent mean percentage of each category in CC (n=10) and PSP subline (n=20) groups.
  5. *P<0.05, ***P<0.001, comparison between CC and PSP values. ND, not determined.
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