Table 3 Basal levels and changes of molecular parameters after treatment according to clinical response on 27 evaluable patients

	No. of positive samples at trucut	Median value at trucut ^a [IQR]	No. of positive samples at surgery	Median difference between trucut and surgery [IQR]	P -value
ERα-p-Ser¹¹⁸
Total	27/27	90 [90, 90]	26/26	−25 [−65, −5]	<0.001^b
CR	13/13	90 [90, 90]	12/12	−25 [−55, −5]	0.68^c
NR	14/14	90 [90, 90]	14/14	−25 [−75, −5]
pHER2
Total	10/27	0 [0, 5]	8/26	0 [−5, 0]	0.49^b
CR	6/13	0 [0, 5]	5/12	0 [0, 0]	0.73^c
NR	4/14	0 [0, 3]	3/14	0 [−5, 0]
ER-β
Total	23/27	48 [5, 90]	23/26	10 [0, 60]	0.02^b
CR	11/13	60 [5, 90]	10/12	10 [0, 60]	0.66^c
NR	12/14	41 [5, 80]	13/14	9 [−10, 42]
p-p38
Total	11/27	0 [0, 3]	13/26	0 [−3, 20]	0.10^b
CR	5/13	0 [0, 3]	5/12	0 [−3, 20]	0.68^c
NR	6/14	0 [0, 3]	8/14	0 [−3, 12]
p-p44/42
Total	23/27	10 [5, 15]	18/26	−5 [−10, 28]	0.78^b
CR	12/13	10 [10–15]	8/12	−3 [−10, 30]	0.66^c
NR	11/14	9 [3–10]	10/14	−5 [−10, 24]

CR=clinical responders; IQR=interquartile range; NR=non-responders.
^aValues are expressed as percentage of stained cells.
^bChange of the expression of molecular parameters among all tumours assessed by the Wilcoxon signed-rank test.
^cChange of the expression of the molecular parameters between clinical responders and non-responders assessed by the Mann–Whitney U-test.

Quick links

Search