Table 3 Sensitivities and specificities of CT, US abdomen, EUS, US neck, and chest X-ray only and the number of false-positive and false-negative results and the accuracy rates plus 95% confidence intervals for CT, US abdomen, EUS, US neck, and chest X-ray only and the combinations of CT and the other investigations in patients with oesophageal or gastric cardia cancer

From: Detection of distant metastases in patients with oesophageal or gastric cardia cancer: a diagnostic decision analysis

 

Sensitivity

Specificity

False-positive: false-negative

Accuracy rate

95% confidence interval

Liver (n=335, 26 metastases)

 CT

19/26 (73%)

299/309 (97%)

10 : 7

0.95

0.92–0.97

 USa

17/26 (65%)

308/309 (99%)

1 : 9

0.97

0.95–0.99

 CT+USa: 1 positive

  

10 : 6

0.95

0.92–0.97

 CT+USa: 2 positive

  

1 : 10

0.97

0.94–0.98

Celiac lymph nodes (n=143, 32 metastases)

 CT

22/32 (69%)

102/111 (92%)

9 : 10

0.87

0.80–0.92

 USa

14/32 (44%)

111/111 (100%)

0 : 18

0.87

0.81–0.92

 EUS

12/32 (38%)

104/111 (94%)

7 : 20

0.81

0.74–0.87

 CT+EUS: 1 positive

  

11 : 6

0.88

0.82–0.93

 CT+EUS: 2 positive

  

5 : 24

0.80

0.72–0.86

 CT+USa: 1 positive

  

9 : 6

0.90

0.83–0.94

 CT+USa: 2 positive

  

0 : 22

0.85

0.78–0.90

 CT+USa+EUS: 1 positive

  

11 : 5

0.89

0.82–0.93

 CT+USa+EUS: 2 positive

  

5 : 13

0.87

0.81–0.92

 CT+USa+EUS: 3 positive

  

0 : 30

0.79

0.71–0.85

Supraclavicular lymph nodes (n=546, 58 metastases)

 CT

16/58 (28%)

484/488 (99%)

4 : 42

0.92

0.89–0.94

 USn

49/58 (85%)

484/488 (99%)

4 : 9

0.98

0.96–0.99

 CT+USn: 1 positive

  

7 : 8

0.97

0.96–0.98

 CT+USn: 2 positive

  

1 : 43

0.92

0.89–0.94

Lung (n=424, 19 metastases)

 CT

17/19 (90%)

399/405 (99%)

6 : 2

0.98

0.96–0.99

 CXR

13/19 (68%)

404/405 (99%)

1 : 6

0.98

0.97–0.99

 CT+ CXR: 1 positive

  

7 : 0

0.98

0.97–0.99

 CT+ CXR: 2 positive

  

0 : 8

0.98

0.96–0.99

  1. CT=computed tomography; CXR=chest X-ray; EUS=endoscopic ultrasonography; USa=ultrasound abdomen; USn=ultrasound neck.