Table 3 Relative risks of lung cancer in women using 1 to 2 or 15 or more aspirin tablets per week by duration of use and by latency period between aspirin assessment and lung cancer diagnosis

From: Aspirin and lung cancer risk in a cohort study of women: dosage, duration and latency

 

1–2 aspirin tablets per week

15 aspirin tablets per week

Duration of use a

P-Yb

Cases

RRc (95% CId)

P-Yb

Cases

RRc (95% CId)

 <2 years

202.5

119

0.86 (0.68–1.07)

27.0

33

1.68 (1.15–2.45)

 2–5.9 years

153.8

81

0.87 (0.67–1.14)

21.1

20

1.44 (0.90–2.30)

6 years

69.5

29

0.75 (0.50–1.19)

15.1

11

1.49 (0.81–2.76)

P for trende

  

0.66

  

0.31

Latency period f

P-Yg

Cases

RRc (95% CId)

P-Yg

Cases

RRc (95% CId)

 0 to <2 yearsh

445.1

234

0.84 (0.70–1.02)

65.6

65

1.55 (1.17–2.06)

 2 to <4 years

397.7

238

0.88 (0.73–1.05)

57.8

53

1.24 (0.92–1.68)

 4 to <6 years

359.5

240

0.91 (0.76–1.09)

50.3

51

1.19 (0.88–1.62)

 6 to <8 years

323.2

256

1.02 (0.86–1.22)

43.2

45

1.15 (0.84–1.59)

  1. Abbreviations: P-Y=person–years; RRs=relative risks; CI=confidence intervals.
  2. aDuration was calculated as continuous years of aspirin use among current users.
  3. bP-Y of follow-up, in thousands, from 1980 to 2004.
  4. cRRs adjusted for age, smoking status, age at start of smoking (past and current smokers), years since quit smoking (past smokers), and cigarettes per day (current smokers).
  5. d95% CI.
  6. eP-value for linear trend over median values within categories of years of aspirin use.
  7. fDuring the latency periods for users of 1–2 aspirin tablets per week, women were censored if they reported 15 tablets per week; during the latency periods for users of 15 aspirin tablets per week, women were censored if they reported 1–2 tablets per week.
  8. gP-Y of follow-up, in thousands, through 2004 and beginning in 1980 for a latency of 0 to <2 years; in 1982 for a latency of 2 to <4 years; in 1984 for a latency of 4 to <6 years; and in 1986 for a latency of 6 to <8 years.
  9. hA latency of <2 years is the same as current users in Table 2 because aspirin use was assessed every 2 years.