Table 3 Cox's proportional hazards model (univariate) of relapse of disease

From: Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer

 

Crude model

Adjusted model

 

Crude HR

95% CI

P -value

Adjusted HR

95% CI

P -value

CD3 intratumoral 294/118

0.48

[0.27–0.86]

0.01

0.49

[0.28–0.86]

0.01

CD3 peritumoral 795/2043

0.27

[0.13–0.58]

0.0008

0.29

[0.14–0.61]

0.001

CD4 intratumoral 16/213

0.55

[0.31–1.00]

0.05

0.55

[0.31–1.00]

0.05

CD4 peritumoral 106/463

0.62

[0.39–0.99]

0.04

0.61

[0.38–0.98]

0.04

CD8 intratumoral 198/852

0.41

[0.21–0.81]

0.01

0.41

[0.21–0.80]

0.009

CD8 peritumoral 448/1234

0.38

[0.20–0.74]

0.004

0.37

[0.19–0.73]

0.004

  1. HR=hazard ratio.
  2. Cox's proportional hazards regression modeling was performed to determine the association between density of immune cells and relapse of disease. In the model the cell density at the 25 and 75% percentiles was compared, densities shown for each cell type. The model was adjusted for age at diagnosis and FIGO stage.
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