Table 2 Univariate and multivariate analyses of factors for adenomas carrying both K-ras/BRAF mutations and RASSF2 methylation

From: Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features

  

Both K-ras/BRAF mutation and RASSF2 methylation

 

All adenomas

n (%)

Univariate analysis OR (95% CI)

Multivariate analysis OR (95% CI)

Total

120

21 (18)

  

Female

34

8 (24)

1.73 (0.64–4.64)

1.51 (0.50–4.53)

Age (⩾65)

61

14 (23)

2.21 (0.82–5.95)

1.56 (0.54–4.53)

Distal colon

49

3 (6)

0.19 (0.05–0.69)†

0.13 (0.03–0.58)‡

Flat type

41

9 (22)

1.43 (0.55–3.69)

0.54 (0.16–1.84)

Size (⩾2 cm)

41

10 (24)

1.99 (0.77–5.19)

1.86 (0.59–5.94)

Serrated adenoma

8

5 (63)

10.00 (2.17–46.00)*

11.11 (1.96–63.00)**

  1. Abbreviations: OR, odds ratio; CI, confidence interval. †P=0.01, ‡P=0.007, *P=0.003, **P=0.007.
Back to article page