Figure 2 | British Journal of Cancer

Figure 2

From: Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo

Figure 2

Antiproliferative effect of Titanocenes X and Y, Cp2TiCl2 and cisplatin on HeLa and A431 cells. HeLa (A and B) and A431 (C and D) cells were treated with vehicle (DMSO (0.5% v/v)) or 0.5, 5, 50 and 250 μ M of the indicated compound for 24 h (A and C) and 48 h (B and D). Cell viability was determined using an MTT assay and absorbance was monitored spectrophotometrically at 540 nm. Results represent the mean±s.e.m. of three separate experiments. (E) IC50 values±s.e. from Cp2TiCl2, cisplatin, Titanocenes X and Y treatment of HeLa and A431 cells for 48 h, calculated using the PRISM statistical analysis software package.

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