Figure 7
R306465 inhibits tumour growth in vivo after oral administration. Nude mice were injected s.c. with A2780 ovarian, H460 lung or HCT116 colon carcinoma cells (107 cells per mouse) and subsequently treated p.o. with vehicle (control group, 20% HP-β-CD; •) or R306465 at either 10 (○), 20 (▴) or 40 mpk (▿). Mice were treated orally once daily (q.d.) between day 4 and 28 (A2780) or between day 4 and 32 (H460 and HCT116). (A) A2780 ovarian tumours were measured at least twice a week throughout the study, and results are represented as the median tumour size, expressed in mm3, of each individual group (n=10). (B) Mice were treated orally q.d. at the indicated doses. Results are represented as the treated/control values (%) of the median tumour size (n=10) at the end of the study.
