Figure 5
From: Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours
ERRFI1 in exon 4 in NB tumours. Bars under each chromatogram indicate the mutation position. (A) Upper panel: The 1028A>G mutation in patient 25R9 leads to an amino-acid substitution from Asn to Ser. Middle panel: Normal tissue from patient 25R9, heterozygous for A/G. Lower panel: Healthy control individual. (B) Upper panel: 1186C>A variation in patient 24R3. Middle panel: Normal tissue from patient 24R3, homozygous for the C allele. Lower panel: Healthy control individual. (C) Alignment of amino-acid sequences. The putative mutation, marked with red, is located in a highly conserved region.
