Table 2 Hazard ratios for each pathological feature assessed adjusted for age and gender
Characteristics | Hazard ratio | Lower 95% CI | Upper 95% CI | P -value | |
|---|---|---|---|---|---|
Local invasion | T1 | 1.00 | |||
T2 | 1.22 | 0.97 | 1.53 | 0.09 | |
T3 | 2.10 | 1.71 | 2.58 | <0.01 | |
T4 | 4.35 | 3.53 | 5.36 | <0.01 | |
Unknown | 1.92 | 1.24 | 2.98 | <0.01 | |
N stage | N0 | 1.00 | |||
N1 | 1.77 | 1.64 | 1.91 | <0.01 | |
N2 | 3.22 | 2.95 | 3.51 | <0.01 | |
Unknown | 1.57 | 1.31 | 1.88 | <0.01 | |
Extramural vascular invasion | Present | 1.00 | |||
Absent | 0.41 | 0.37 | 0.44 | <0.01 | |
Unknown | 0.55 | 0.50 | 0.60 | <0.01 | |
Peritoneal involvement | Present | 1.00 | |||
Absent | 0.42 | 0.39 | 0.45 | <0.01 | |
Unknown | 0.52 | 0.46 | 0.59 | <0.01 | |
Tumour perforation | Present | 1.00 | |||
Absent | 0.44 | 0.36 | 0.53 | <0.01 | |
Unknown | 0.56 | 0.47 | 0.67 | <0.01 | |
Distance of invasion beyond the muscularis propria (T3's only)(mm) | 0–1 mm | 1.00 | |||
1.1–5 | 0.67 | 0.58 | 0.77 | <0.01 | |
5.1–10 | 0.83 | 0.73 | 0.94 | <0.01 | |
10.1–15 | 1.03 | 0.89 | 1.20 | 0.67 | |
>15 | 1.24 | 1.02 | 1.50 | 0.03 | |
Unknown | 1.43 | 1.19 | 1.72 | <0.01 | |
CRM status | Involved | 1.00 | |||
Uninvolved | 0.43 | 0.37 | 0.51 | <0.01 | |
Unknown | 0.51 | 0.41 | 0.63 | <0.01 | |
Number of nodes examined | 0–6 | 1.00 | |||
7–12 | 0.95 | 0.88 | 1.03 | 0.21 | |
>12 | 0.85 | 0.79 | 0.93 | <0.01 | |
Unknown | 1.27 | 0.96 | 1.67 | 0.09 | |
