Table 2 Effect of morphine treatment on survival following high-dose celecoxib treatment

From: COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia

 

Percent of surviving mice after treatment

Treatment type

After day 1

After day 2

After day 10

(i) Vehicle control

100

100

100

(ii) Morphine

100

100

100

(iii) Celecoxib

50

0

—

(iv) Morphine+celecoxib

100

100

100a

  1. After 24 h of SCK tumour cell injection, mice were treated with (a) vehicle control, 50 μl normal saline+50 μl 0.5% methylcellulose; (b) morphine, 0.714 mg per kg mouse per day (equivalent to 50 mg morphine per day per 70 kg human adult) during the first week, followed by 1 mg per kg mouse per day, thereafter; (c) 100 mg celecoxib per kg mouse per day for 1 day; and (d) morphine as described in (b) and celecoxib.
  2. a100 mg per kg mouse per day for one day followed by 30 mg per kg per day.
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