Figure 3
From: Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice
(A) Cellular ATP content during exposure to 20 μ M FCCP (circles), 10 μ M LCL-30 (squares) and 20 μ M LCL-30 (triangles). Results are mean±s.d. of n=4 and normalised to protein content. (B) Ratio of cytosolic to mitochondrial cytochrome c at different durations of incubation with 10 μ M LCL-30, as assessed by ELISA. (C) Caspase-3-activity after 6 h of exposure to 10 μ M LCL-30.
