Table 2 ROC curve-derived cut-off scores, area under the curve (AUC) and association of protein expression with complete pathologic response
Cut-off score | AUC (95% CI) | Total ( n) | No complete response, n (%) | Complete response, n (%) | P -value | OR (95% CI) |
|---|---|---|---|---|---|---|
p53 | ||||||
⩽50% | 0.529 (0.39–0.66) | 92 | 41 (70.7) | 17 (29.3) | 0.359 | 1.55 (0.61–3.96) |
>50% | 22 (64.7) | 12 (35.3) | ||||
VEGF | ||||||
⩽20% | 0.64 (0.51–0.77) | 89 | 12 (48.0) | 13 (52.0) | 0.004 | 0.23 (0.09–0.63) |
>20% | 49 (76.6) | 15 (23.4) | ||||
Bcl-2 | ||||||
⩽20% | 0.546 (0.41–0.68) | 90 | 49 (72.1) | 19 (27.9) | 0.203 | 2.02 (0.68–5.99) |
>20% | 13 (59.1) | 9 (40.9) | ||||
APAF-1 | ||||||
⩽10% | 0.538 (0.41–0.67) | 88 | 40 (71.4) | 16 (28.6) | 0.137 | 2.07 (0.8–5.38) |
>10% | 20 (62.5) | 12 (37.5) | ||||
EGFR | ||||||
⩽20% | 0.66 (0.54–0.78) | 90 | 40 (80.0) | 10 (20.0) | 0.003 | 5.78 (1.85–18.07) |
>20% | 22 (55.0) | 18 (45.0) | ||||
