Table 4 Non-haematological toxicity (by patients and cycles)
Grade (% of patients, n =43) a | Grade (% of cycles, n =246) a | |||||||
|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |
Nausea | 53.5 | 20.9 | 0 | 0 | 30.1 | 6.1 | 0 | 0 |
Vomiting | 20.9 | 16.3 | 0 | 0 | 8.9 | 3.7 | 0 | 0 |
Stomatitis | 16.3 | 11.6 | 0 | 0 | 6.9 | 2.4 | 0 | 0 |
Diarrhoea | 44.2 | 0 | 0 | 0 | 13.8 | 0 | 0 | 0 |
Constipation | 48.8 | 14.0 | 2.3 | 0 | 20.7 | 3.7 | 0.4 | 0 |
Asthenia | 58.1 | 37.2 | 4.7 | 0 | 72.4 | 11.8 | 0.8 | 0 |
Alopecia | 0 | 97.7 | — | — | 4.1 | 82.1 | — | — |
Neuropathy | 48.8 | 41.9 | 2.3 | 0 | 53.7 | 18.7 | 1.2 | 0 |
Hand–foot syndrome | 46.5 | 16.3 | 9.3 | 0 | 31.7 | 10.2 | 2.8 | 0 |
Nail toxicity | 23.3 | 11.6 | 2.3 | 0 | 17.1 | 8.9 | 0.4 | 0 |
Myalgia | 48.8 | 16.3 | 2.3 | 0 | 32.9 | 7.7 | 0.4 | 0 |
Arthralgia | 53.5 | 23.3 | 9.3 | 0 | 32.5 | 11.0 | 1.6 | 0 |
Elevated transaminase | 14.0 | 2.3 | 0 | 0 | 4.9 | 0.8 | 0 | 0 |
Hyperbilirubinaemia | 14.0 | 4.7 | 0 | 0 | 7.3 | 1.6 | 0 | 0 |
