Table 2 Patient survival in dependence of several clinicopathological factors and HDAC isoform expression (n=150)
Characteristic | No. of cases | No. of events | Mean PSA-relapse-free time (±s.e.) in months | P -value |
|---|---|---|---|---|
HDAC1 expression | 0.256 | |||
Low | 53 | 18 | 112 (±10) | |
High | 97 | 41 | 97 (±9) | |
HDAC2 expression | 0.004 | |||
Low | 42 | 9 | 134 (±13) | |
High | 108 | 50 | 86 (±7) | |
HDAC3 expression | 0.089 | |||
Low | 9 | 1 | 148 (±15) | |
High | 141 | 58 | 101 (±7) | |
Pre-OP PSA | 0.006 | |||
⩽10 ng ml−1 | 72 | 20 | 117 (±8) | |
>10 ng ml−1 | 73 | 37 | 75 (±10) | |
Age | 0.336 | |||
⩽65 | 105 | 44 | 99 (±9) | |
>65 | 45 | 15 | 108 (±12) | |
pT stage | 0.003 | |||
pT2 | 78 | 22 | 111 (±9) | |
pT3/pT4 | 72 | 37 | 84 (±10) | |
Histological grade (Gleason) | <0.001 | |||
Gleason sum 2–6 | 59 | 12 | 127 (±9) | |
Gleason sum 7 | 51 | 22 | 95 (±12) | |
Gleason sum 8–10 | 40 | 25 | 50 (±8) | |
R-status | 0.006 | |||
R0 | 79 | 23 | 122 (±9) | |
R1 | 71 | 36 | 76 (±10) | |
Ki-67 index | 0.010 | |||
⩽10% | 95 | 34 | 104 (±8) | |
>10% | 34 | 21 | 62 (±14) |
