Table 3 Predictive factors of clinical response (>50%) according to univariate and multivariate analyses

From: High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies

   

Univariate analysis

Multivariate analysis

 

N

CR (%)

P

RR (IC 95%)

P

RR (IC 95%)

Age

 >40

548

58

 

1

  

 ⩽40

138

55

0.6

0.9 (0.6–1.3)

  

Menopause

 No

512

56

    

 Yes

174

61

0.3

1.2 (0.8–1.7)

  

Clinical tumour stage

 cT2

515

60

    

 cT3

171

51

<0.05a

0.7 (0.5–0.99)

0.12

0.7 (0.5–1.1)

Clinical nodal status

 cN0

425

56

    

 cN1

261

60

0.3

1.2 (0.9–1.6)

  

Histological type

 Ductal

617

59

    

 Lobular

69

43

0.02

0.5 (0.3–0.9)

0.23

0.7 (0.4–1.3)

Hormonal receptors b

 HR+

433

55

    

 HR−

144

65

0.03

1.5 (1.0–2.3)

0.09

1.4 (0.9–2.1)

Histological grade

 Grade 1

113

42

 

1

 

1

 Grade 2

360

59

0.003

1.9 (1.3–3.0)

0.02

1.8 (1.1–3.0)

 Grade 3

213

63

<10−3

2.3 (1.4–3.7)

0.02

2.0 (1.1–3.4)

  1. ER=estradiol receptor; HR=hormonal receptor; PR=progesterone receptor.
  2. aFactors entered in the multivariate analysis.
  3. bHR+ if ER+ and/or PR+.
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