Table 5 Univariate and multivariate analyses of prognostic factors for locoregional recurrence-free survival

From: High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies

   

Univariate analysis

Multivariate analysis

 

N

10-year LRRFS (%) (IC 95%)

P a

RR (IC 95%)

P b

RR (IC 95%)

Age (continuous variable)

  

0.015

0.97 (0.96–1.00)

  

Age (dummy variable) c

<10−6

 

<10−3

 

 >40

597

79 (75–82)

 

1

 

1

 ⩽40

153

60 (51–70)

 

2.2 (1.6–3.1)

 

2.3 (1.6–3.2)

Menopause

0.5

   

 No

563

73 (69–78)

 

1

  

 Yes

187

79 (73–86)

 

0.9 (0.6–1.3)

  

Clinical tumour stage c

0.35

   

 cT2

556

74 (69–78)

 

1

  

 cT3

194

78 (72–86)

 

0.8 (0.6–1.2)

  

Clinical nodal status c

0.33

   

 cN0

465

76 (71–80)

 

1

  

 cN1

285

74 (68–80)

 

1.2 (0.8–1.6)

  

Histological type

0.9

   

 Ductal

672

75 (71–79)

 

1

  

 Lobular

78

73 (62–86)

 

1 (0.6–1.7)

  

Hormonal receptors c

0.05

 

0.02

 

 HR+

466

75 (71–80)

 

1

 

1

 HR−

166

69 (62–78)

 

1.4 (1.0–2.0)

 

1.7 (1.2–2.5)

Histological grade

0.34

   

 Grade 1

114

82 (75–90)

 

1

  

 Grade 2

362

73 (68–79)

 

1.3 (0.8–2.0)

  

 Grade 3

217

73 (67–81)

 

1.4 (0.9–2.4)

  

Mitotic index

0.48

   

 Grade 1

182

79 (72–87)

 

1

  

 Grade 2

189

77 (70–84)

 

1.2 (0.7–1.9)

  

 Grade 3

297

75 (69–81)

 

1.3 (0.8–2.0)

  

Clinical response

0.72

   

 ⩾50%

434

78 (74–83)

 

1

  

 <50%

309

76 (70–82)

 

1.1 (0.8–1.5)

  
  1. HR=hormonal receptor; LRRFS=locoregional recurrence-free survival
  2. aLog-rank test.
  3. bLikelihood ratio test.
  4. cFactors entered in the multivariate analysis.
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