Table 7 Univariate and multivariate analyses of prognostic factors for overall survival

From: High rates of breast conservation for large ductal and lobular invasive carcinomas combining multimodality strategies

   

Univariate analysis

Multivariate analysis

 

N

10-year LRRFS (%)(IC 95%)

P

RR (IC 95%)

P

RR (IC 95%)

Age (continuous variable)

  

0.7

1.0 (0.99–1.02)

  

Age (dummy variable)

0.11

   

 >40

597

67 (63–72)

 

1

  

 ⩽40

153

60 (52–69)

 

1.3 (0.9–1.7)

  

Menopause a

0.22

   

 No

563

67 (63–72)

 

1

  

 Yes

187

63 (55–71)

 

1.2 (0.9–1.6)

  

Clinical tumour stage a

0.005

   

 cT2

556

68 (64–73)

 

1

  

 cT3

194

59 (51–67)

 

1.5 (1.1–1.9)

  

Clinical nodal status a

<10−7

 

<10−3

 

 cN0

465

73 (69–78)

 

1

 

1

 cN1

285

54 (48–61)

 

2.0 (1.6–2.6)

 

2.1 (1.6–2.7)

Histological type

0.44

   

 Ductal

672

65 (61–69)

 

1

  

 Lobular

78

72 (62–84)

 

0.8 (0.6–1.3)

  

Hormonal receptors (HR) a

<10−7

 

<10−3

 

 HR+

466

70 (66–75)

 

1

 

1

 HR−

166

49 (42–58)

 

2.2 (1.7–2.8)

 

2.4 (1.8–3.2)

Histological grade a , b

0.0004

 

0.02

 

 Grade 1

114

78 (69–87)

 

1

 

1

 Grade 2

362

66 (61–71)

 

1.8 (1.1–2.8)

 

1.8 (1.1–2.8)

 Grade 3

217

58 (51–66)

 

2.5 (1.6–3.9)

 

1.9 (1.2–3.1)

Mitotic index a

<10−4

   

 Grade 1

182

77 (70–85)

 

1

  

 Grade 2

189

67 (60–74)

 

1.6 (1.1–2.4)

  

 Grade 3

297

59 (53–65)

 

2.2 (1.5–3.2)

  

Clinical response a

0.15

 

0.003

 

 ⩾50%

434

67 (63–73)

 

1

 

1

 <50%

309

64 (58–70)

 

1.2 (0.9–1.6)

 

1.5 (1.2–2.0)

  1. HR=hormonal receptor; LRRFS=locoregional recurrence-free survival
  2. aFactors entered in the multivariate analysis.
  3. bThe mitotic index was not entered into the model as it was highly correlated with the histological grade.
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