Figure 3

Kaplan–Meier metastasis-free overall survival estimates of RCC patients with clinically confined disease according coexpression of caveolin-1 with (A) pAKT, (B) pmTOR, (C) pS6 and (D) p4E-BP1. Patients who coexpressed caveolin-1 and activated components of the AKT/mTOR pathway had significantly worse prognosis compared with patients whose tumours were negative for either biomarker and/or had single biomarker-positive expression.