Figure 1

Cortactin expression in normal oral mucosa and HNSCC. Staining of cortactin was performed as indicated in Materials and Methods. Normal epithelium (A–B) is devoid of staining, arrowheads indicate cortactin staining of blood vessels. Scale bar represents 200 μm in the tissue core shown in panel A and 100 μm in the higher magnification images shown in panels B–F. (C–D) Squamous cell carcinoma demonstrating strong membrane and cytoplasmic staining, respectively. (E) Squamous cell carcinoma exhibiting weak staining. (F) Squamous cell carcinoma displaying absence of immunohistochemical staining. Only strong staining (C–D) was scored as cortactin overexpression. Weak staining or absence of staining (E–F) was scored as negative for this study. Calibration bar represents 200 μm in images on the left.