Table 1 Comparison of cortactin and EGFR status to demographic, clinical, and pathologic data
Cortactin status a | EGFR status a | |||||||
---|---|---|---|---|---|---|---|---|
n | − | + | P | n | − | + | P | |
Patient cohort | ||||||||
Age (years) 37–82 (median 63) | ||||||||
Interpretable for cortactin | 176 | 99 | 77 | |||||
Interpretable for EGFR | 176 | 66 | 110 | |||||
Positive control | ||||||||
Interpretable for cortactin | 7 | 0 | 7 | |||||
Noninterpretable | 1 | |||||||
Interpretable for EGFR | 9 | 2 | 7 | |||||
Noninterpretable | 2 | |||||||
Gender | ||||||||
Male | 138 | 76 | 62 | 0.11 | 138 | 36 | 102 | 0.13 |
Female | 38 | 23 | 15 | 38 | 30 | 8 | ||
Site | ||||||||
Oral cavity | 40 | 20 | 20 | 0.42 | 40 | 10 | 30 | 0.39 |
Pharynx | 57 | 42 | 15 | 57 | 21 | 36 | 0.11 | |
Larynx | 79 | 66 | 13 | 79 | 35 | 39 | ||
TNM stage | ||||||||
I | 34 | 15 | 19 | 0.005† | 34 | 24 | 10 | 0.004† |
II | 44 | 19 | 25 | 44 | 20 | 24 | ||
III | 48 | 15 | 23 | 48 | 16 | 32 | ||
IV | 50 | 12 | 38 | 50 | 14 | 36 | ||
Grade | ||||||||
Well differentiated | 27 | 15 | 12 | 0.001† | 27 | 16 | 11 | 0.001† |
Moderately differentiated | 94 | 24 | 70 | 94 | 34 | 60 | ||
Poorly differentiated | 55 | 11 | 44 | 55 | 11 | 44 |