Table 2 Univariate and multivariate Cox regression analyses by cortactin expression levels
Cortactin status | Mean time to recurrence (months) | Percentage of recurrence (95% confidence interval) | Hazard ratio (95% confidence interval) | P |
|---|---|---|---|---|
Univariate | ||||
Local recurrence | ||||
Overexpressor | 32.0 | 49.1% (39–66) | 6.032 (1.6–27.1) | 0.014 |
Nonoverexpressor | 47.0 | 28.0% (16–49) | 0.169 (0.05–0.8) | |
Disease-free survival | ||||
Overexpressor | 22.2 | 61.5% (40–81) | 2.586 (1.2–5.9) | 0.007 |
Nonoverexpressor | 34.7 | 17.5% (11–29) | 0.379 (0.3–0.8) | |
Overall survival | ||||
Overexpressor | 29.2 | 57.8% (35–80) | 2.275 (1.2–4.7) | 0.024 |
Nonoverexpressor | 42.5 | 20.9% (11–30) | 0.425 (0.3–0.9) | |
Multivariate | ||||
Variable | Hazard ratio | 95% confidence interval | P | |
Local recurrence | ||||
Tumour type | 1.675 | 0.8–3.7 | — | 0.20 |
TNM stage | 1.412 | 0.8–2.4 | — | 0.20 |
Histologic grade | 0.965 | 0.6–1.6 | — | 0.90 |
Cortactin overexpressor | 5.293 | 1.2–23.6 | — | 0.029* |
Disease-free survival | ||||
Tumour type | 1.616 | 0.9–3.0 | — | 0.13 |
TNM stage | 1.453 | 1.0–2.1 | — | 0.06 |
Histologic grade | 1.033 | 0.7–1.5 | — | 0.87 |
Cortactin overexpressor | 3.000 | 1.3–7.0 | — | 0.010* |
Overall survival | ||||
Tumour type | 1.648 | 0.9–3.1 | — | 0.12 |
TNM stage | 1.679 | 1.1–2.5 | — | 0.014* |
Histologic grade | 0.984 | 0.7–1.5 | — | 0.94 |
Cortactin overexpressor | 2.449 | 1.1–5.7 | — | 0.038* |
