Table 2 Toxicity
Level 1, L-OHP (100 mg m−2), n =3 | Level 2, L-OHP (130 mg m−2), n =29 | |||||
|---|---|---|---|---|---|---|
All (%) | G3 (%) | G4 (%) | All (%) | G3 (%) | G4 (%) | |
Non-haematologic | ||||||
Nausea | 1 (33) | 0 | 0 | 21 (72) | 0 | 0 |
Vomiting | 0 | 0 | 0 | 7 (24) | 0 | 0 |
Diarrhoea | 1 (33) | 0 | 0 | 17 (59) | 1 (3) | 0 |
Fatigue | 1 (33) | 0 | 0 | 25 (86) | 0 | 0 |
Anorexia | 2 (67) | 0 | 0 | 26 (90) | 0 | 0 |
Rush | 3 (100) | 0 | 0 | 13 (45) | 0 | 0 |
Pigmentation disorder | 1 (33) | 0 | 0 | 22 (76) | 0 | 0 |
Hand–foot syndrome | 0 | 0 | 0 | 0 | 0 | 0 |
Peripheral neuropathy | 3 (100) | 0 | 0 | 29 (100) | 0 | 0 |
Allergic reaction | 0 | 0 | 0 | 0 | 1 (3) | 0 |
Haematologic | ||||||
Neutropaenia | 2 (67) | 0 | 0 | 18 (62) | 4 (14) | 0 |
Leukopaenia | 2 (67) | 0 | 0 | 20 (69) | 0 | 0 |
Thrombocytopaenia | 3 (100) | 1 (33) | 0 | 27 (93) | 7 (24) | 1 (3) |
Anaemia | 1 (33) | 0 | 0 | 18 (62) | 1 (3) | 0 |
