Figure 1
From: Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells
The effects of CPEC with respect to CTP depletion and to the anabolism of dFdC in human pancreatic carcinoma (Panc-1, Miapaca-2 and BxPC-3) and NSCLC cells (SWp and its dFdC-resistant variant SWg). Cellular CTP/UTP ratios relative to untreated controls are shown as means with standard errors of at least three separate experiments for the dose dependency at 24 h after CPEC (A) and for the kinetics after exposure to 1000 nM CPEC (B). Incorporation of dFdC into DNA as a function of CPEC dose for 48 h preincubation are shown as means with standard errors of at least three separate experiments (C).
