Table 1 Immunohistochemical assessment of NGAL expression in pancreatitis and PDAC

From: Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia

Tissue specimen

N

Average composite score

Normal pancreas

8

1±0

Pancreatitis

4

1±0

Adenocarcinoma

27

4.26±2.44a

  1. N=specimen number; NGAL=neutrophil gelatinase-associated lipocalin; PDAC=pancreatic ductal adenocarcinoma.
  2. The staining intensity was graded on a scale of 0–3 (0=no staining, 1=weak, 2=moderate, and 3=strong staining). The percentage of cells that were positive for NGAL were scored as follows: 1=<25% cells positive, 2=25–50% cells positive, 3=50–75% cells positive, and 4=75–100% cells positive. The staining intensity score and percent positivity score for each section were multiplied to obtain a composite score for that section. The composite score ranged from 0 to 12.
  3. aThe difference in the staining score between normal and adenocarcinoma of the pancreas was statistically significant: P<0.0001.
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