Figure 5 | British Journal of Cancer

Figure 5

From: Low expression of γ-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype

Figure 5

Simplified representation of folate transport and polyglutamylation reactions within the cell. RFC1 is ubiquitously expressed in epithelial cells and plays a role as a major transport system for folates. FOLR1 is anchored to cell membranes and transports folates via an endocytotic process. Intracellular monoglutamyl folate is converted to the polyglutamate form by FPGS, whereas the polyglutamate chains are removed by GGH.

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