Table 2 Associations between mRNA expression and CIMP status in CRC from an Australian cohort

From: Low expression of γ-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype

 

mRNA expression level

 

Gene symbol

CIMP+

CIMP−

P -value

CDA

3.44 (1.79–5.05)

2.08 (0.92–4.28)

0.131

DCK

2.78 (2.57–3.22)

2.49 (1.67–3.00)

0.025

DCTD

4.21 (3.52–5.21)

4.04 (3.00–5.24)

0.403

DHFR

4.67 (3.52–5.37)

3.72 (2.84–5.38)

0.129

DPYD

0.48 (0.32–0.76)

0.32 (0.24–0.48)

0.025

DUT

123.8 (53.6–196.8)

116.2 (68.1–166.2)

0.828

ECGF1

4.76 (3.16–7.08)

2.71 (1.93–4.01)

0.001

FOLR1

0.00 (0.00–0.07)

0.10 (0.00–0.43)

0.060

FPGS

0.77 (0.56–0.95)

0.70 (0.52–0.85)

0.458

GGH

1.97 (1.04–3.06)

3.31 (1.98–5.69)

0.013

MTHFD1

4.46 (3.76–5.11)

3.84 (2.90–5.08)

0.197

MTHFR

1.20 (0.97–1.40)

0.91 (0.65–1.34)

0.044

RFC1

2.97 (2.29–4.30)

2.91 (1.99–3.92)

0.923

RRM1

1.02 (0.84–1.29)

0.96 (0.65–1.27)

0.265

RRM2

6.96 (4.60–7.70)

3.51 (2.27–6.03)

0.004

TYMS

3.32 (2.48–5.81)

2.99 (1.91–4.24)

0.099

UMPS

1.17 (1.07–1.40)

1.29 (0.96–1.73)

0.660

  1. CIMP=CpG island methylator phenotype; CRC=colorectal cancer.
  2. mRNA expression levels are shown as median (25th to 75th percentiles).
  3. The Mann–Whitney U-test was used for statistical analysis.
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