Table 4 Associations between mRNA expression level and the concentration of folate intermediates in CRC from an Australian cohort

From: Low expression of γ-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype

 

CH 2 FH 4

FH 4

Gene symbol

Spearman's ρ

P -value

Spearman's ρ

P -value

CDA

0.205

0.063

0.154

0.163

DCK

0.058

0.583

0.056

0.599

DCTD

−0.042

0.684

0.024

0.817

DHFR

−0.081

0.448

−0.145

0.174

DPYD

0.020

0.845

0.010

0.924

DUT

−0.022

0.834

−0.022

0.834

ECGF1

0.062

0.559

0.043

0.686

FOLR1

−0.136

0.190

−0.073

0.481

FPGS

−0.025

0.807

0.023

0.822

GGH

−0.200

0.053

−0.180

0.083

MTHFD1

−0.014

0.856

−0.033

0.752

MTHFR

−0.028

0.784

0.037

0.720

RFC1

−0.159

0.123

−0.205

0.046

RRM1

0.039

0.707

0.006

0.952

RRM2

0.107

0.303

0.046

0.661

TYMS

0.076

0.471

−0.018

0.864

UMPS

−0.121

0.246

−0.050

0.630

  1. CRC=colorectal cancer.
  2. Spearman's rank correlation test was used for analyses.
  3. Spearman's ρ and P-value are presented for each analysis of correlations.
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