Figure 1

Box plot illustrating correlation between BMI-1 protein expression and mRNA BMI-1 expression. Among samples with low BMI-1 protein expression, there is a highly significantly lower level of BMI-1 mRNA expression (A). Cases with vascular invasion show significantly lower level of BMI-1 mRNA expression (B). Low BMI-1 expression was seen in 25 (44%) samples compared with high expression in 32 (56%) samples. Examples of high immunohistochemical BMI-1 expression are illustrated in panel C and low expression in panel D.