Table 1 BMI-1 protein expression in tumours related to clinicopathologic variables and biomarkers in a population-based study of endometrial carcinomasa

From: Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma

 

BMI-1 expression b

 
 

Low

High

 

Variable

n (%)

n (%)

P- value

FIGO stage

  

0.39

 I/II

118 (56)

94 (44)

 

 III/IV

25 (49)

26 (51)

 

Histologic subtype

  

0.43

 Endometrioid

127 (53)

111 (47)

 

 Non-endometrioid

16 (62)

10 (38)

 

Histologic grade (FIGO)

  

0.38

 Grades 1–2

112 (53)

100 (47)

 

 Grade 3

31 (60)

21 (40)

 

Vascular invasion

  

<0.0001

 Not present

74 (44)

93 (56)

 

 Presentc

69 (71)

28 (29)

 

Myometrial infiltration

  

0.004

 <50%

56 (49)

58 (51)

 

 ⩾50%

50 (70)

21 (30)

 

ER

  

0.001

 Low expression

44 (77)

13 (23)

 

 High expression

85 (51)

82 (49)

 

PR

  

0.03

 Low expression

46 (69)

21 (31)

 

 High expression

84 (53)

74 (47)

 
  1. ER=estrogen receptor; FIGO=Federation of Gynecology and Obstetrics; PR=progesterone receptor.
  2. Two hundred and sixty-four cases with evaluable staining for BMI-1 (Upstate), missing data for FIGO stage in 1 case, depth of myometrial infiltration in 79 cases, for ER in 40 cases, and for PR in 39 cases.
  3. bMedian used as cut-off value.
  4. cVascular invasion of tumour cells detected in ⩾2 vessels.
Back to article page