Table 2 Most common non-haematologic AEs (grades 3 and 4) occurring in more than one patient in any cohort, during treatment with chemotherapy
Cohort 1 ( n =13) | Cohort 2a ( n =13) | Cohort 2b ( n =19) | ||||
|---|---|---|---|---|---|---|
AE | Grade 3 n (%) | Grade 4 n (%) | Grade 3 n (%) | Grade 4 n (%) | Grade 3 n (%) | Grade 4 n (%) |
Diarrhoea | 0 | 0 | 4 (31) | 0 | 3 (16) | 0 |
Fatigue | 0 | 0 | 4 (31) | 0 | 3 (16) | 0 |
Rash/desquamation | 0 | 0 | 3 (23) | 0 | 2 (10) | 0 |
Dehydration | 0 | 0 | 1 (8) | 0 | 3 (16) | 0 |
Dysphagia | 0 | 0 | 0 | 1 (8) | 2 (10) | 0 |
Nausea | 0 | 0 | 3 (23) | 0 | 0 | 0 |
Abdominal pain | 0 | 0 | 1 (8) | 0 | 1 (5) | 0 |
Dermatology/skin other | 1 (8) | 0 | 0 | 0 | 1 (5) | 0 |
Dizziness | 0 | 0 | 1 (8) | 0 | 1 (5) | 0 |
Stomatitis/pharyngitis | 0 | 0 | 0 | 0 | 2 (10) | 0 |
Fainting | 0 | 0 | 1 (8) | 0 | 1 (5) | 0 |
Vomiting | 0 | 0 | 2 (15) | 0 | 0 | 0 |
