Figure 5 | British Journal of Cancer

Figure 5

From: SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy response

Figure 5

The effect of 5-Aza in combination with 5-FU on apoptosis was assessed by caspase 3/7 assay (A) and B) TUNEL assay (blue, DAPI nuclear stain; green, TUNEL-positive cells). (P<0.05 for ‘*’ when compared with 5-FU treatment; ‘**’ comparison between 5-FU only vs SPARC siRNA(+)/5-FU(+) treated cells; and ‘***’ comparison between 5-Aza(+)/5-FU(+) and 5-Aza(+)/5-FU(+)/SPARC siRNA(+)). Results represented as mean±s.e.

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