Table 1 GSTM1, T1 and P1 allele frequencies and BC HR in BRCA1/2 carriers (adjusted for origin, Ashkenazi vs non-Ashkenazi)

From: Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers

Genotype

BC− ( n =109) no. (%)

BC+ ( n =211) no. (%)

Average age at BC onset (years)

Breast cancer HR (95% CI)

P -value

GSTM1 (n=320)

 Present

46 (42.2)

106 (50.2)

41.4

1

 

 Null

63 (57.8)

105 (49.8)

42.9

0.89 (0.65–1.12)

0.25a

GSTT1 (n=319)

     

 Present

84 (77.8)

158 (74.9)

42.5

1

 

 Null

24 (22.2)

53 (25.1)

41.3

1.11 (0.81–1.52)

0.53b

GSTP1 (n=319)

     

 Ile/Ile

76 (70.6)

121 (57.3)

42.1

1

 

 Ile/Val

29 (26.6)

74 (35.1)

42.6

1.36 (1.02–1.81)

0.04c

 Val/Val

3 (2.8)

16 (7.6)

40.5

2.00 (1.18–3.38)

0.01d

  1. BC−, no BC; BC+, with BC; CI, confidence interval; HI, hazard ratio.
  2. Corresponding P-values after correction for multiple comparisons are as follows: a0.50, b0.53, c0.12 and d0.03.
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