11q13 950
131I-MIBG 1053
18FDG 1597
25-OCH3-PPD 792
5-Aza-2′deoxycytidine 1810
5-fluorouracil 716
8-hydroxydeoxyguanosine 580
ABCG2 1515
adaptation 25
ADCC 1217
adenocarcinoma in situ 165
adherens junctions 256
adiponectin 370
adjuvant therapy 25, 1301
adolescence 1475
advanced gastric cancer 316, 1398
advanced non-small cell lung cancer 1769
advanced NSCLC 558
Affymetrix U133 Plus 2.0 array 1403
African 992
age 328
age distributions 277
age-dependent prevalence 646
ageing 619, 677
AIF 803
Akt 803, 1094, 1348, 1525
AKT1 E17K 1533
AKT/mTOR pathway 931
alcohol 1582, 1857
allele frequency 1125
ALT 1467
alternative splicing 129
amino acid transporter 742
anaemia 323
anal cancer 1264
androgen receptor 1094
angiogenesis 250, 776, 923, 1250, 1312, 1348, 1366, 1619, 1646, 1731
annexin 426
anorexia 300
anthracycline-pretreated 1500
anthropometrics 1288
anti-angiogenesis 1250
antibiotics 161
anti-tumour immunity 1258
AP-1 915
Aplidin 1966
apoptosis 370, 399, 803, 824, 941, 1109, 1803
archival formalin-fixed paraffin-embedded tissue 1403
aromatase inhibitors 1494
array CGH 434
Asian and Western populations 9
aspirin 989
asynchronous contralateral breast cancer 728
ATP-binding cassette transporters 380
atypical hyperplasia 45
autologous vaccine 1336
autophagy 399
Axl tyrosine kinase receptor 1141
AZD3409 1951
β-catenin 1886
β-catenin-independent signalling 1437
Barrett's metaplasia 1985
basement membrane 974
BCP ALL 1125
BCRP 857
berberine 363
bevacizumab 1366
bexarotene 1380
BIBW 2992 80
biliary stricture 1548
biliary tract cancer 1548, 1675
biological effect study 1951
biological predictive factors 143
biomarkers 587, 776, 1366, 1731
biopsy 1182
birth outcome 183
birth weight 179, 660, 664, 1288
bisphosphonates 1736
bladder cancer 466
bleomycin 388
BMI-1 1662
body mass index 194, 1582
bone metastasis 809, 1736, 1753
bone turnover 1753
BORIS 571
bortezomib 1500
brachytherapy 450
brain tumour 1285
BRCA1 1457
BRCA1 and BRCA2 502
BRCA1/2 2006
BRCA2 1457
breast cancer 9, 25, 39, 210, 289, 370, 564, 571, 636, 641, 734, 784, 840, 870, 989, 992, 1132, 1141, 1147, 1327, 1380, 1485, 1494, 1500, 1525, 1536, 1641, 1741, 1753, 1790, 1870, 1876, 1182, 2006
breast cancer mortality 206
breast neoplasm 217
breast screening 1741, 1759
breast-conserving surgery 289
British black women 277
burnout 1046
bystander effect 1244
cachexia 300
calcium 1574
cancer biomarker 981
cancer growth 1250
cancer mortality 1012
cancer patients 443
cancer risk 660
cancer risk model 1457
cancer site 1012
cancer stem cells 1389, 1670, 1886
cancer suppressor gene 410
cancer therapy 517
capecitabine 309, 316, 1204, 1320
carbonic anhydrase inhibitor 129
carbonic anhydrase IX 129
carboplatin 1774
carcinogen exposure 619
carcinogenesis 245, 965, 1653
Carcinoid 1053
carcinoma 627, 981
carcinoma of the oral cavity 1039
carcinoma of unknown primary 1425
cardiovascular disease 1586
case-control comparison 1125
case-control studies 161, 168, 174, 179, 206, 652, 992, 1570, 1586, 1852
CASP8 1434
caveolin-1 931
CD133 1389
CD24 756
CD44 756
CDKN2A 434
CDKN2A (p16) 1264
CEA 328, 1217
CEC 1731
cell cycle 523, 824
cell death 98
cell proliferation 981
central laboratory 907
centrosome 345
ceramides 98
ceramidoids 98
cervical cancer 15, 863, 1292
cervical screening 1704
cervical smear 1292
cetuximab (Erbitux®, C225) 120
checkpoint 523
CHEK2*1100delC mutation 728
chemokines 1682
chemoprevention 232, 1157
chemoradiotherapy (CRT) 1670
chemoresistance 335, 803, 1085
chemosensitisation 792
chemotherapy 22, 86, 309, 542, 693, 728, 734, 870, 1197, 1210, 1327, 1769
childhood cancer 1285, 1876
childhood leukaemia 225, 1006
Chk1 523
cholangiocarcinoma 309, 418, 1675
chordoma 434
chromatin 1467
chromosomal radiosensitivity 1723
chromosome instability 345
CIMP 1555
circadian rhythm 1753
circulating progenitor cells 776
cirrhosis 1166
cisplatin 86, 803, 881, 1085, 1803
cJun 915
clinical response 77
clinical study 1312
clinical trial 1452
clinicopathological features 277
c-MYC 1985
cohort 1001, 1929
cohort study 183, 194, 529, 1864
colon cancer 587, 875, 1312, 1366, 1619
colorectal cancer 60, 71, 323, 328, 335, 668, 716, 997, 1034, 1217, 1434, 1555, 1614, 1682, 1810, 1824, 1886, 1999
colorectal carcinogenesis 1437
colorectal neoplasms 98
combination therapy 1234
combined modality 1210
communication 1508
concurrent chemoradiotherapy 881
constitutional chromosome deletions 1929
consultation 1508
contact-inhibition 256
continuity of care 529
contrast agent 1784
cortactin 950, 956
cost-effectiveness 1166, 1762
cost-utility 1166
counter-matching 45
COX-2 1102
CpG arrays 466
CPT-11 335
CT scan 875
CTCF 571
CUP 1425
CXCR4 1682
cyclin D1 950
cyclopentenyl cytosine 1226
CYFRA 21-1 77
CYP1B1 564
CYP3A 91
CYP3A4 1797
CYP3A4 transgenic 1630
cytochrome c release 1525
cytochromes P450 564, 1797
cytology 154
cytoskeleton 256
dairy protein 1574
data modelling and analysis 1023
database 816
decision aid 1769
decision-making 1830
decompensated cirrhosis 1161
dendritic cells 106, 784
depression 1934
deprivation 1006
detection 263
diabetes 1582
diagnosis 60, 323, 1425, 1540, 1562
diagnostic validity 1934
dietary iron 194
dietary lignans 636
differentiation 1415
dihydropyrimidine dehydrogenase 832
dipeptidyl aminopeptidase IV 818
disease/relapse-free survival 1641
DKK1 1147
DNA adducts 1959
DNA damage 480
DNA methylation 816, 824, 1881
DNA methyltransferase 1716
DNA repair 1614
DNA replication 981
docetaxel 542, 558, 894, 1305, 1500, 1608, 1710, 1774
domestic fuel 1586
dominant-negative mutant 915
doxorubicin 1515
drug metabolism 91
drug resistance 564, 923, 1068
drug therapy 98
drug-drug interaction 1320
ductal carcinoma in situ (DCIS) 137
duration of chemotherapy 1197
dysplasia 457
dyspnoea 294
early life exposure 1288
early stage 1191
Ebp1 1132
E-cadherin 489
EDD 1085
education 1012
effectiveness 641
EGF receptor 956
EGFR 154, 256, 450, 923, 1076
eIF2α 443
elderly patients 558
electrochemotherapy 388
electroporation 388
EMA 1562
EML4-ALK 1536
employment 708, 1342
endocrine sensitivity 22
endometrial adenocarcinoma 45
endometrial cancer 1076, 1288, 1582
endometrial carcinoma 1662
endometrial neoplasms 194
endometrioid ovarian cancer 282
endothelium 1731
England 633
EphB4 845
ephrinB2 845
EPIC 1574
epidemiology 161, 183, 641, 652, 1285, 1582, 1852, 1870
epidermal growth factor receptor 80, 418, 749, 832, 1118
epidermal growth factor receptor (EGFR) mutation 907
epigenetics 496, 1485, 1515, 1881
epirubicin 720
epithelial ovarian cancer 1191
epithelial-mesenchymal transition 489, 1993
Epo binding 1059
ER negative 1380
ERBB2 1525
ERCC1 1398
ERK1/2 1525
erlotinib 1774
erythropoietin receptor 1059
ethnicity 633
etoposide 693
Europe 1012
everolimus 923
evidence 1944
excision repair cross- complementing gene 1 832
expression 1059
extracolorectal cancer 997
extremity soft tissue sarcoma 1403
Ezrin 256
FADD 950
FAK 1274
familial cancer 1876
familial risk 840, 997
family history 199
Fanconi anaemia 1653
Fanconi genes 1452
FDG PET 875
fibroblast 1886
fine-needle aspiration cytology 818
first-line chemotherapy 720
FISH 154
FOLFOX 1398
follow up 875
formalin-fixed paraffin- embedded; gene expression; prognostic assay 1999
FOXO1 1068
Foxp3 148, 1258
free radicals 580
FRNK 1274
funding 1944
fusion transcript 1536
G2 523
gallbladder carcinoma 309
gastric cancer 54, 148, 542, 824, 832, 965, 1301, 1443
gastrin 1696
gastrointestinal 1696
gastrointestinal cancer 1536
gastrointestinal stromal tumours 684, 1762
gastro-oesophageal cancer 888
gastro-oesophageal junction tumours 965
GD2 263
Gd-DTPA 1784
gefitinib 71, 716, 907
gemcitabine 558, 881, 1226, 1327, 1710, 1916
gene chip 363
gene expression 245, 587, 1327, 1845
gene expression profiling 1023, 1264, 1403, 1425
gene signature 1662
general population 708
genetic alteration 749
genetic predisposition 728, 1443, 1723
genetic testing 1457
genistein 1485
genomic imbalances 434
genomics 756
geography 1944
geriatric oncology 517
germline mutation 474
GGH 1555
ghrelin 300
GHRH 1790
ginsenoside 792
Gli-1 1670
glioblastoma 113, 1431
glioma 652, 1830
glutathione-S-transferase 2006
grapefruit 1630
green tea 168
growth arrest-specific gene 6 1141
growth factors 250
GSTP1 polymorphism 2006
guidelines 1944
gynaecological 1774
haem iron 194
haematology 1046
HDAC 604
head and neck cancer 1274, 1723
head and neck squamous cell carcinoma 619, 956
health education 1176
Hector Battifora mesothelial antigen-1 818
Hedgehog (Hh) 1670
Helicobacter pylori 689
hepatic transporters 91
hepatitis C virus 580
hepatocellular carcinoma 1161, 1166
HER1/EGFR 1774
HER2 1525
HER2/neu 1076
herceptin 1525
hereditary syndrome 1876
HGF receptor 1102
HIF-2α 965
high dimensionality 1023
high-field MR 1784
histone deacetylase inhibitors (HDACIs) 1234
histopathology 45
HLA-DPB1 1125
HNSCC 950
Hodgkin's disease 183
hormone receptors 1662
hormone replacement therapy 194
hormone therapy 870
hormone-refractory prostate cancer 1094
hospital referral 1176
HPV 627
HPV screening 15
HPV typing 1704
HPV vaccination 1704
HPV vaccines 15
hTERT 1467
hTR 1467
human epidermal growth factor receptor 2 418
human papillomavirus 646, 863, 1264
human parvovirus B19 611
humanised monoclonal antibody 1525
hypermethylation 1690, 1716
hypoxia 129, 965, 1975
hypoxia-inducible factor-1 (HIF-1) 1975
ICAM2 1357
ifosfamide 720
imatinib 1633, 1762
imatinib mesylate 684
immunocytochemistry 263
immunohistochemistry 137, 418, 426, 450, 580, 587, 604, 1662
immunotherapy 784, 1336
in vivo tumour inhibition 1250
incidence 165, 633, 989
indisulam 1320
inequality 668
infant acute leukaemia 664
infectious aetiology hypothesis 225
inflammation 91, 1443, 1646
informed consent 1769
INI1 474
interaction analysis 1508
internal ribosome entry 1696
interstitial pneumonitis 1870
intra-arterial chemotherapy 1039
intracranial invasion 363
intrauterine factors 664
invasion 113, 356, 1274
invasive breast cancer 277
invasive ductal carcinoma 1993
invasiveness 1348
ionising radiation 1226
Iran 1857
irinotecan 693, 1210, 1312, 1619
iron 580
job satisfaction 1046
job stress 1046
ketoconazole 1797
Ki-67 742, 1525
kinesin spindle protein 894
kinetic analysis 1597
KIT 684
lactate 1975
lactation 189, 992
laminin-332 974
lapatinib 1076
large G protein 410
larynx 950
LAT1 742
late effect 1001
lay terms 34
leukaemia 168, 1006, 1633
linear and nonlinear clearance 900
linear discriminant analysis 457
lipocalin 1540
liposarcoma 1467
LMO4 537
locally advanced 1210
locally advanced breast cancer 1745
LOH 1830
lomeguatrib 1614
long-term follow-up 863
long-term risk 870
long-term survival 720
longitudinal studies 1342, 1475
loss of heterozygosity 410, 1690
lower urinary tract symptoms 1903
lung adenocarcinoma 1710
lung and prostate cancer 1790
lung cancer 232, 270, 1109, 1602, 1608, 1653
lymph node metastasis 1389, 1682, 1824
lymphocyte 1845
lymphoma 161
macrophage 1118
MAD 1985
male radiographer 1759
malignancy 91
malignant glioma 345
malignant melanoma 106
mammary stem cell 1485
mammographic density 210
mammography 217, 641, 1182
markers 1830
markov models 1762
mass screening 217
mathematical model 113
matrix metalloproteinases 250, 766
matuzumab 900
MCAK 1824
MCM 1548
MCM7 1264
Mdm2 (Hdm2) 4
Mdm4 (MdmX, Hdm4, HdmX) 4
mechanisms of genomic alterations 1653
medical record linkage 1570
MEFs 480
melanoma 179, 1922
men 1012, 1864
meningioma 652
menopause 1288
menstrual cycle phase 39
Merlin 256
mesothelioma 1562
Met 1102
meta-analysis 547, 1934
metabolic syndrome 194
metabolism 1630
metalloproteinases 689, 1820
metastasis 86, 106, 931, 1415
metastatic 1500
metastatic breast cancer 1916
metastatic gastric carcinoma 1305
methylation 410, 466, 496, 1147, 1431, 1810
methyl-CpG-binding domain proteins 1881
metronomic chemotherapy 1312, 1619
microarray analysis 480
microarrays 1023, 1264, 1327, 1425
microenvironment 250, 809
microRNA 410
microsatellite 619
mistletoe lectin 106
mitochondrion 1839
mitotic kinesin 894
MLL rearrangements 664
MMP-2 1274
MMP-8 766
MMTV-erbB2 1380
mobile phone 652
modelling studies 270, 1166
modifiers 2006
molecular targeting 941
monoclonal antibody 749, 900
morphological types 199
mortality 1864
mouse brain 1784
MRI 113, 289
mRNA 1431, 1662
MS-275 1234
mTOR 923
MUC-1 784, 1562
mucin glycoprotein 1675
multicentre prospective phase II 907
multidrug resistance 857, 1515
multimodality 734
multiple myeloma 1966
murine models 1966
muscle atrophy 443
mutation 154, 619, 1533
mutational analysis 684
MV3 106
myosin IIA 596
natural products 792
near-infrared Raman spectroscopy 457
neoadjuvant chemotherapy 289, 734, 1327
neoplasms 294, 1586
NER 120
nested case-control study 1295
neuroblastoma 263
neuroendocrine 1053
neurotoxicity 1959
NF-κB 71, 335
NGAL 1540
nimotuzumab 749
nitric oxide 1803
nitric oxide synthase 1839
NKD1 1437
NM23-H1 363
NO-aspirin 1157
nodal dissection 54
noncoding RNA 981
non-Hodgkin 161
non-small cell lung cancer 77, 154, 742, 749, 907, 915, 1118, 1536, 1716
non-steroidal anti-inflammatory drugs 232, 1781
normal tissue response 1845
NOS 1803
NPC 363
nuclear factor-κB 611
nuclear survivin 1109
nude mice 1525
nutrition 300
O6-methylguanine-DNA methyltransferase 1614
odds ratio 1295
oesophageal adenocarcinoma 1102, 1985
oesophageal cancer 547, 689, 974, 1670, 1857
oestrogen 766
oestrogen receptor 370, 571, 636, 766
older patient 517
oncogene 1533
oncology 1046, 1508, 1597
opium 1857
optical diagnosis 457
oral cancer 633
oral contraceptives 1781
oral squamous cell carcinoma 1258, 1357
oropharynx 627
OSI-420 1630
OSI-774 1630
osteoclast 809
osteoclastogenesis 809
osteolysis 809
outcome 537, 1029
outcome prediction 1830
ovarian cancers 282, 489, 720, 845, 1068, 1085, 1197, 1415, 1452, 1781, 1803, 1910
overall survival 489, 1641
oxaliplatin 120, 309, 542, 1034, 1204, 1959
oxidative stress 580, 1157
oxygen 294
p53 4, 1431, 1803
p70S6k 443
PA2G4 1132
paclitaxel 316, 1068
paediatric brain tumour 474
paediatrics 1570
PAK1 1132
palliative care 294
Panax notoginseng 792
pancreatic cancer 537, 881, 1226, 1389, 1540, 1548, 1690
pancreatic neoplasms 189
PanIN 1540
papillary thyroid carcinoma 611
paracrine 245
parathyroid hormone 1753
parenteral oestrogen 697
parity 199, 1295, 1781
participating patients 34
PDGFRA 684
pegylated liposomal doxorubicin 1916
penetrance 474
peptide-binding pockets 1125
peroxisome proliferating- activated receptor 1415
PET 1597
pH control 129
pharmacodynamics 1633, 1959
pharmacoepidemiology 232
pharmacogenetics 1633
pharmacogenomics 1710
pharmacokinetics 80, 98, 517, 1320, 1633, 1797, 1959
phase I study 80, 894, 1029, 1320
phase I/II study 1034, 1305
phase II study 716, 1336
Phellinus linteus 1348
phosphoinositide-dependent protein kinase 1 1415
phosphorylation 1132
physical activity 174, 1864
PI3K pathway 974
PKB 1525
PKR 443
platinum 1959
platinum resistance 1452
policy 641
poliglumex 1608
polymorphisms 689, 857, 1434, 1443
polyoxomolybdate 399
pooled analyses 282
population density 225, 1006
population mixing 1006
population movements 225
population pharmacokinetic 900
population-attributable fraction 199
population-based 179
postoperative adjuvant chemotherapy 596
PR1A3 1217
predicting factor 1389
pregnancy 183, 189
prematurity 1570
prenatal exposure 660
prenyl transferase inhibitor 1951
pre-operative radiotherapy 450
preoperative therapy 1745
prevention 1292, 1380
primary health care 323, 1176
principal components analysis 457
progesterone receptor 282, 571, 636
progesterone receptor B 1141
PROGINS 282
prognosis 148, 418, 426, 537, 627, 931, 956, 1102, 1258, 1716, 1820, 1824, 1876, 1910
prognostic factors 742, 832, 845, 974, 1029, 1039, 1161, 1745, 1993
prognostic markers 604, 1403
progress 1191
proliferation 113, 370, 1109, 1244
promoter methylation 1555
prospective 1574
prospective studies 39, 1342
prostate 245, 1852
prostate cancer (PCa) 22, 250, 356, 502, 604, 697, 756, 792, 1234, 1244, 1574, 1903
prostate pathology 502
prostate-specific antigen 1176
proteasome inhibitor 1500
protein 1059
proteomics 426
pyruvate 1975
pyruvate dehydrogenase kinase 1 (PDK-1) 1975
qPCR 587
QRT-PCR (quantitative real-time polymerase chain reaction) 1845
quality of life 25, 54, 888, 1494, 1903
quality-adjusted survival 25
quantitation 1597
quantitative reverse-transcriptase polymerase chain reaction (qPCR) 1641
radiation 1210, 1852
radiation therapy 728, 1039, 1845
radiation-induced bystander effects 1839
radiochemotherapy 1204
radiographer gender 1759
radionuclide 1053
radioresistance 1357
radiosensitisation 749, 792, 1226
radiosensitivity 345
radiotherapy 734, 870, 1001
rapamycin 931
reactive oxygen spices (ROS) 1068
real-time PCR 1999
receptor tyrosine kinase 1525
rectal cancer 143, 450, 1204, 1210
recurrence 1085, 1922
red meat 194
redox 1157
refractory 716
regulatory T cells 148
re-induction 22
relative deprivation 633
relative risk 199
relative survival 328
renal cell carcinoma 496, 931, 941, 1336
replication 120
reproductive history 189, 992
resection 113
resistance 1525
responder to uracil-tegafur 596
response to therapy 1525
retinoic acid metabolism-blocking agents (RAMBAs) 1234
return-to-work 1342
rexinoid 1380
rhabdoid tumour predisposition syndrome 474
risk 636, 863, 1434, 1929
risk assessment 840
risk factors 168, 210
risk prediction 270
RRM1 1710
RRM2 1710
RT-PCR 1830
RUNX3 1690
S-1 1034, 1301, 1305
sarcoma 1633
SB-715992 894
screening 206, 641, 646, 1182, 1602
screening history 1292
SDF-1α 1682
second malignancies 870, 1001
secreted phospholipase A2 587
semaxinib 1619
seminal vesicle 356
senescence 245, 250, 1244
sensitivity 1602, 1934
sentinel lymph node 1922
serous 1085
service delivery 529
SFRP 1147
side population 380
signal transduction inhibitors 1633
signalling 370
signalling pathway 1839
single-step selection 1515
siRNA 1357
Smac 941
small molecule inhibitors 4
small-cell lung cancer 693
SMF 210
smoking 1475, 1582
Snai1 489
Snai2 480
SNIP 1641
SNPs (single nucleotide polymorphisms) 282, 1820, 1845
socio-economic factors 217
socioeconomic status 277, 668
South Africa 1586
SOX 1034
SOX2 824
soy 9, 1485
SPARC 1810
specificity 1602
splice variant 1250
squamous cell carcinoma 380, 766, 1274
stage 668, 888
stage I lung adenocarcinoma 596
staging 328, 547
stem cells 380, 480, 660, 857
stomach 457
stomach cancer 1295
stomach cancer survivor 708
stroma 1886, 1993
sunitinib 1762
superoxide dismutase 776
supertypes 1125
supportive care need 1903
surgery 1745
surgical resection 537
surveillance 1166
survival 39, 263, 1029, 1741, 1820
survival analysis 217, 1118
survival prediction 77
survivin 345, 627, 1109
survivin-deltaEx3 1109
syndecan-1 1993
systematic review 60, 697
systemic therapy 1769
tamoxifen intolerance 1494
Tarceva 1630
targeted therapy 677, 684, 857
telomerase 1467
telomeres 677
temozolomide 1614
temsirolimus 1797
testicular cancer 174
testicular neoplasms 171
tetrathiomolybdate 776
therapeutic response 537
therapy 1161
three drug combination 693
thrombospondin-1 1312
thymidylate synthase 143
thyroid nodule 818
thyroid peroxidase 818
timing of surgery 39
tissue microarray 137, 426, 956
TNF 1443
tobacco 1586, 1653, 1857
tongue 766
topoisomerase-IIα 1910
transcript 1059
transforming growth factor-β1 356
transitional cell carcinoma 86
transitions in care 529
translation 1696
trastuzumab 1525
treatment 888, 1944
treatment decisions 1769
treatment delay 1197
treatment induced bone loss 1736
Treg 1258
trial 54
trial results 34
triple negative 277
triplets 720
TS 1398
tumor invasion 1646
tumour advancement 845
tumour classification 137, 1425
tumour development 1525
tumour load 1922
tumour marker 1675
tumour stem cells 756
tumour suppressors 1485
tumours 1059, 1784
twins 171, 1475
tyrosine kinase inhibitor 80
ultrasound 1285
uptake 1759
urbanisation 1006
urokinase-type plasminogen activator 356
USPIO 1784
uterine cancer 45
vaccination 646
vascular disruption 388
vascular endothelial growth factor 418
vascular invasion 931
vasculature 1731
VEGF 450, 1250, 1366, 1784
VEGF165b 1366
VEGF-C 1389
vimentin 596
viral protein 611
virus DNA 611
VN/66-1 1234
Wnt 1147
Wnt signalling 1437
women 1012
work ability 708, 1342
wound healing 1646
XIAP 941
young adults 1475
zoledronic acid 1753
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Keyword Index for Volume 98. Br J Cancer 98, 2025–2028 (2008). https://doi.org/10.1038/sj.bjc.6604447
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DOI: https://doi.org/10.1038/sj.bjc.6604447