Figure 1
From: VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis
Schematic diagram summarising the different ways in which the VEGF and Notch pathways interact. (A) VEGF stimulus, acting via VEGF-R2, increases expression of Dll4 on endothelial cells, which in turn activates Notch receptors on adjacent endothelial cells. (B) Activated Notch receptors on endothelial cells can in turn positively (VEGF-R1, VEGF-R3) or negatively (VEGF-R2) regulate the expression of VEGF receptors in those cells.
